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This is another example of the interaction between environmental
and genetic factors. Offspring who are obese and have one
or both parents with diabetes develop diabetes much more
frequently than offspring who are similarly obese but
whose parents are not diabetic. On the other hand, in
offspring with low or normal body mass index, the
prevalence is little influenced by the diabetic state of
their parents. This finding can only be explained as an
effect of the interaction between the environmental and
genetic determinants.
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