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Four different consequences of the action of neurotransmitters. These events show that the synapses and nucleus readily interact Transmitter activation of a ligand-gated ion channel leads to a rapid synaptic action lasting milliseconds to seconds. Transmitter activation of a seven transmembrane receptor and a second messenger kinase leads to a more enduring synaptic action lasting minutes. Repeated transmitter activation of a seven transmembrane receptor leads to the translocation of the kinase to the nucleus and to activation of transcription, producing a persistent synaptic action lasting days. Transmitter can also activate local protein synthesis to stabilize the synapse-specific long-term facilitation.   Go to Comment Form