Conducted at Framingham town, Messachusets, to find out the association between the coronary artery disease and the risk factors like high serum cholesterol, hypertension, smoking etc.

Framingham town was selected as it is compact, economically stable, more cooperative and represents U.S. population to a larger extent (though sample is only 68%)

In 1948, a Cardiovascular demonstration programme was carried out in Framingham town. Later, in the year 1951, it was converted into a cohort study.