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The fraction of the exposed controls was estimated to correspond to the 10% of the population of the district living in the vicinity of the emission source
(< 5 km from ENO plant).

Which parameter of the statistical power calculation is the limiting factor?

-> the cases occurring in the observation perion in this selected district

How can the power be improved?

-> (1) increase the matching factor, but:

The available budget allowed only a 1:1 frequency matching.

-> (2) One-sided test can be taken into account, because a protective efffect of arsenic exposure on skin cancer development can likely be excluded.