front |1 |2 |3 |4 |5 |6 |7 |8 |9 |10 |11 |12 |13 |14 |15 |16 |17 |18 |19 |20 |21 |22 |23 |24 |25 |26 |review |
Resistance =
arginine, R, at 171 Susceptibility = glutamine, Q, at 171 The other 2 amino acids have a less marked effect but are considered in the scoring scheme of clinical scrapie risk ( R ) where R1= resistant and R5= fully susceptible The alleleles may delay but not prevent ataxia at 7y instead of 2y How is this applied to flock improvement? Genotyping of rams is by DNA-sequencing of a PCR-amplified fragment of wbc from EDTA
blood, (avoid heparin which can interfere with PCR), is now provided by the Veterinary
laboratory agency (VLA) and Scottish Agricultural Colleges (SAC). |