By histology new variant CJD (nvCJD) has larger 'florid' areas of plaques of prion protein and vacuoles than spontaneous CJD and occurs in younger people. This florid lesion is also seen in human Kuru and in macaques experimentally infected with BSE by the intracerebral route. Variant CJD also contains BSE-like and not scrapie or spontaneous CJD prions when classified by molecular weight gels and mouse- incubation period, see Nature in 1997, vol 389, pp 437-438, 448-450, 498-501. In the period of 1994-August 2000 79 cases of nvCJD were recognised in UK, 3 in France, 1 in Eire. Portugal, like the UK, now has above 100 cases of BSE per 1 million adult cattle and could be an at-risk place for humans to eat BSE-infected beef and develop nvCJD. Greece supplies no data and is also considered to be high risk for nvCJD.