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3.
Neuroleptic malignant syndrom. Neuroleptic malignant syndrom is a rare but
serious complication, similar to the malignant hypertermia syndrom seen with certain
anesthetics. It occurs in 1% to 2% of patients and is fatal in almost 10% of those
affected. This is observed early in treatment and is characterized by a near complete
collapse of the autonomic nervous system, causing, for example, fever, muscle rigidity,
diaphoresis, mental confusion and cardiovascular instability. Immediate medical
intervention with bromcriptine (DA agonist) and dantrolene is nessesary. |