One thing that has become abundantly clear since the disease was recognized 100 years ago is that for the vast majority of patients that increase in blood pressure are not pathophysiologically important. We're not talking about really high blood pressure and we're not talking about real dysfunction to the point that women are sick from it. So you have to be awfully careful when you're trying to prevent a disease that is based on pure signs that you understand all that well, that you're not just preventing the diagnosis. You want to be sure that you're preventing something about the disease that matters. For example, if you had a drug that lowers blood pressure and prevents proteinuria, would you really be reducing the incidence of preeclampsia, or have you just prevented the diagnosis? The ravages that are hurting the mother and the baby continue in a vast amount of treatment.