Pharmacovigilance is the science of collecting, monitoring, researching, assessing, and evaluating of current safety drug information from healthcare providers (primarily from spontaneous reporting), aiming the early identification of drug safety problems, their quantitative (frequency) and qualitative characterization (seriousness, severity, reversibility, mechanism and public health implications) and prevention of harm to patients (through the identification of risk factors and groups of risk and the implementation of regulatory actions toward risk management). Effective and open communication of safety information, supporting health education, is the final and challenge goal of Pharmacovigilance.