Causality inference obtained by the clinical judgement of an expert's panel (named global introspection) is the most universal used method for individual causality assessment of adverse drug reports. Its internal validity lies on the small probability of different results in the consensus obtained for similar conditions, whilst its external validity remains to be studied.

Despite its usefulness, the global introspection method of causality assessment has been subject to criticisms of subjectivity and imprecision once it is mainly based on expert clinical judgements.