An orthodontist by profession, Othoman Mellouk joined the Association de Lutte Contre le Sida (ALCS) in Morocco in 1994, where he participated in the development of the first prevention program targeting men having sex with men in North Africa and the Middle East.

From 2002 to 2010 he was the chair of the Marrakech city branch of ALCS, and was in charge of international relations of ALCS. He is one of the most active advocates for access to treatment in the MENA region with a particular focus on the question of intellectual property rights and their effect on access to treatment.

He has published several articles and reports about access to medicines in Morocco and the MENA region and been involved in research on monitoring access to treatment progress with the Treatment Monitoring and Advocacy Project of ITPC.

In January 2010, Othoman Mellouk became co-chair of the MSM Global Forum and is also now serving as an Advocacy Officer for ITPC in North Africa.