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This slide
explains that IR is not just an impaired biological response to insulin, but
specifically, that there is resistance to insulin-stimulated glucose uptake,
particularly in the muscle, and unregulated overproduction of glucose by the
liver.1,2 1. Ramlo-Halsted B, et al. The natural history of type 2 diabetes: practical points to consider in developing prevention and treatment strategies. Clin Diabetes. 2000;18(2):80-84. 2. Reaven GM. Banting lecture 1988: Role of insulin resistance in human disease. Diabetes. 1988;37:1595-1607. Lebovitz H. Clin Chem. 1999;45(8B):1339-1345. |