front |1 |2 |3 |4 |5 |6 |7 |8 |9 |10 |11 |12 |13 |14 |15 |16 |17 |18 |19 |20 |21 |22 |23 |24 |25 |26 |27 |28 |29 |30 |31 |review

PPARalpha and PPARgamma play a key role in type 2 diabetes and in lipid metabolism. Activated PPARalpha mainly stimulates fatty acid catabolism in the liver by inducing the expression of genes controlling the beta-oxidation. While activated PPAR-gamma promotes lipid storage in adipose tissue by inducing the expression of lipogenic genes and adipocyte differentiation.