front |1 |2 |3 |4 |5 |6 |7 |8 |9 |10 |11 |12 |13 |14 |15 |16 |17 |18 |19 |20 |21 |22 |23 |24 |25 |26 |27 |28 |29 |review

To analyze the controls that regulate viability, multiplication, and differentiation of normal hematopoietic cells, it is desirable and convenient to study the entire process in cell cultures starting from single cells. Therefore, my analysis began with the establishment of a cell culture system for the cloning and clonal development of different types of hematopoietic cells. This cell culture system made it possible to discover a family of cytokines that regulate cell viability, multiplication, and differentiation of different hematopoietic cell lineages; to analyze the changes in normal controls in some hematological diseases including leukemia; and to identify new ways of treating these diseases.