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But there was no such increased susceptibility after downregulation of bcl-2 by dexamethasone (113, 114) owing to upregulation of another apoptosis suppressing gene bcl-XL (114). Apoptosis is controlled by the balance between apoptosis inducing and apoptosis-suppressing genes. To increase cancer cell susceptibility to induction of apoptosis, it will be necessary to select the appropriate compound for downregulation of those apoptosis-suppressing genes that suppress apoptosis in a particular cancer.