Key Point: In the STELLAR trial, the 10-mg dose of rosuvastatin lowered LDL-C
more effectively than atorvastatin 10 mg and the 10-mg to 40-mg doses of simvastatin
and pravastatin.

This slide shows data from the STELLAR trial comparing rosuvastatin, atorvastatin, simvastatin and pravastatin across their respective dose ranges

Rosuvastatin 10 mg resulted in a statistically significant greater percentage reduction in LDL-C compared with atorvastatin 10 mg; simvastatin 10 mg, 20 mg, or 40 mg; and pravastatin 10 mg, 20 mg, or 40 mg (P<.002)

In a comparison of dose-response curves, rosuvastatin 10 mg to 40 mg reduced LDL-C significantly more than atorvastatin 10 mg to 80 mg (4.1%; P<.001)

Reference

Jones PH, Davidson MH, Stein EA, et al. Comparison of the efficacy and safety of rosuvastatin
versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR Trial). Am J Cardiol. 2003;93:152-160.