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Fig. (1). Fiborsis development. Sinusoidal events during fibrosing liver
injury. Changes in the subendothelial space of Disse and sinusoid as fibrosis develops in
response to liver injury include alterations in both cellular responses and extracellular
matrix composition. Stellate cell activation leads to accumulation of scar
(fibril-forming) matrix. This in turn contributes to the loss of hepatocyte microvilli and
sinusoidal endothelial fenestrae, which result in deterioration of hepatic function.
Kupffer cell(macrophage) activation accompanies liver injury and contributes to paracrine
activation of stellate cells (as in Friedman SL. J Biol Chem 2000 Jan 28;275(4):2247-50
Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue
injury). |