This association may also partly explain the relatively more rapid disease progression in adult post-transfusion cohorts, as the median age at infection in these studies was generally 40 to 50 years. One can speculate that the difference in the fibrosis rates estimated by Poynard et al. and Ghany et al. may be due to the fact that patients in the latter cohort were younger, had less advanced fibrosis on initial liver biopsy, and consumed lesser quantities of alcohol [1, 2].