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Rate of erythropoyesis: even when it is not a direct regulatory factor, if the rate of erythropoyesis increases, iron uptake by bone marrow increases, transferrin saturation fall and iron absorption increases. Physiological state: periods of rapid growth, as pregnancy, infancy and adolescence present higher by increasing iron uptake by tissues. Gastric juice: Achlorhydria reduces absorption of non-heme iron Stomach emptying: iron is released from food by the effect of hydrochloridric acid, so the longer the food stays in the stomach, the greater the amount of iron absorbed. Pancreatic secretions: Pancreatic juice can enhance iron absorption by releasing amino acids from foods, which can act as absorption promoting ligands.