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Mixed Distribution Model

Mixed-distribution analysis is another methodology been used with the same purpose. Several studies have shown that hemoglobin distribution from anemic and non-anemic overlap as shown in the following figure.
If a cutoff point is used as indicated by the red line, a variable proportion of normal subjects will be considered anemic (false positives). On the other hand a variable proportion of anemic subjects will be diagnosed as normal (false negatives).
It has been demonstrated that higher sensitivity can be obtained combining Serum Ferritin, Transferrin Saturation and Free Eritrocyte Protoporfiring using cutoff points.
Two models have been applied: the "MCV model" including MCV, transferrin saturation and erythrocyte protoporphyrin, and the "ferritin model" including serum ferritin, transferrin saturation and erythrocyte protoporphyrin.