c) The n-3 EPA and DHA each modulate several ion currents, whereas pharmaceutical drugs tend to be specific for a single or couple of cardiac ion channels so that it requires a number of drugs acting together to inhibit the same group of ion channels.
d) The drugs act on heart cells to increase the number of ion channels per cardiomyocyte through an effect of the drug on sodium channel gene expression, whereas the n-3 fish oils do not induce such an action, as we have reported comparing mexiletine and EPA on cultured rat heart cells. f) It seems appropriate with the drugs to refer to their physiological effects as blocking or inhibitory, since they are capable of eliminating physiologic effects, whereas the n-3 fatty acids modulate action in a gentler manner as they reduce but do not seem to eliminate physiologic or biochemical processes in our bodies.