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Ten years after the enforcement of nation-wide
vaccination since 1984, the universal vaccination has been proved to be a
successful way to control HBV infection in a high-prevalent endemic
area, and also the mortality from HCC in childhhood has decreased.
A total of 1,515 children under the age of 12 years were enrolled in
this study. The overall prevalence rate of serum HBsAg significantly
decreased from 9.8 % in 1984 to 1.3 % in 1994 (Chen,H-L;JAMA; 276:906, 1996). The
corresponding rate of mortality from HCC also decreased
(Chang,M.H.:NEJM;336:1855, 1997).
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