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Within the CARE
trial, the effect of statin therapy on CRP level was completely independent of the
underlying lipid response. CARE patients who had inflammation present and those who had
inflammation absent had identical levels of total cholesterol, LDL-C, HDL-C, and
triglycerides at baseline. Reference:
Ridker PM, Rifai N, Pfeffer MA, Sacks FM, Moye LA, Goldman S, Flaker GC, Braunwald E, for
the Cholesterol and Recurrent Events (CARE) Investigators. Inflammation, pravastatin, and
the risk of coronary events after myocardial infarction in patients with average
cholesterol levels. Circulation 1998;98:839-844.
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