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For a full discussion please refer to our original article in The Lancet:

1. Shakespeare TP, Gebski VJ, Veness MJ, Simes J. Improving interpretation of clinical studies by use of confidence levels, clinical significance curves, and risk-benefit contours. Lancet. 2001: 357: 1349–53.

Also you can download a free Confidence Calculator for our methods: http://www.theshakespeares.com/confidence_calculator.html