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A good example is the WHO melanoma study published in the Lancet (Ref 20). They randomized 252 patients with truncal melanoma to immediate dissection versus observation and dissection delayed until relapse. 20. Cascinelli N, Morabito A, Santinami M, MacKie RM, Belli F, on behalf of the WHO Melanoma Programme. Immediate or delayed dissection of regional nodes in patients with melanoma of the trunk: a randomised trial. Lancet 1998; 351: 793–6. |