CSCs can be constructed for any comparison: eg OS, local control, toxicity. Alternatively, the information can be displayed in tabular form, at say 5% increments of difference.

We can combine CSCs (eg survival with toxicity), to form Risk-Benefit Contours (RBCs).

RBCs allow us to calculate the confidence associated with acceptable risk-benefit scenarios.

This next study showed a large survival benefit, as well as a high acute toxicity detriment: we will examine the confidence associated with both.