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Intergroup study 0099 (ref 23). Chemoradiotherapy vs radiotherapy for Stage III and IV nasopharynx cancer. Results 3 year survival 78% v 47% (p=0.005) Grade 3 or 4 acute toxicity 76% v 50%. This study showed a large survival benefit, as well as a high acute toxicity detriment. 23. Al-Sarraf M, LeBlanc M, Giri PGS et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. J Clin Oncol 1998; 16: 1310–17.