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This phenomenon
is best seen in this slide, which demonstrates marked predictive value for four
inflammatory markers: ICAM-1, interleukin-6, serum amyloid A, and hs-CRP, even among the
apparently healthy women in the Women's Health Study whose LDL cholesterol was already at
target according to NCEP guidelines, that is to say, less than 130 mg/dL in a
primary-prevention setting. Reference:
Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of
inflammation in the prediction of cardiovascular disease in women. N Engl J Med
2000;342:836-843.
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