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Each statin
studied significantly reduced CRP levels. Median percent reduction in hs-CRP did not
differ significantly among statins; atorvastatin reduced hs-CRP by a median of 28.3%,
pravastatin by 20.3%, and simvastatin by 22.8%. With the respective statins, CRP was
reduced in 81.8%, 72.7%, and 81.8% of patients; CRP was reduced with all three statins in
54.6% of patients. Change in CRP level was not significantly correlated with change in
LDL-C or HDL-C but was correlated with triglyceride (r=0.59, p=0.005). Reference:
Jialal I, Stein D, Balis D, Grundy SM, Adams-Huet B, Devaraj S. Effect of hydroxymethyl
glutaryl coenzyme A reductase inhibitor therapy on high sensitive C-reactive protein
levels. Circulation 2001;103:1933-1935.
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