In 83 healthy obese women (mean BMI 33.8 ± 0.4 kg/m², range 28.2–43.8 kg/m²), CRP was positively associated with BMI at baseline (r=0.281, p=0.01). Subjects with CRP below the median of 5.8 mg/L had significantly lower BMI at baseline (33.0 ± 0.5 kg/m²) than subjects with CRP above the median (BMI 34.8 ± 0.6 kg/m²; p=0.02). BMI accounted for 7.7% of variability in baseline CRP (p=0.01). After 12 weeks on a very low fat, energy-restricted diet (mean 5700 ± 60 kJ/d, 14.2 ± 0.2% fat), CRP was reduced by 26% (p<0.001). Average weight loss was 7.9 ± 0.3 kg and was associated with change in CRP. Change in CRP was also correlated with change in total cholesterol (r=0.240, p=0.03) but not changes in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), or glucose. At 12 weeks, CRP concentration was highly correlated with triglyceride concentration (r=0.287, p=0.009), but not with other lipids or glucose at baseline or 12 weeks.

Reference:
Heilbronn LK, Noakes M, Clifton PM. Energy restriction and weight loss on very-low-fat diets reduce C-reactive protein concentrations in obese, healthy women. Arterioscler Thromb Vasc Biol 2001;21:968-970.
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