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Cell adhesion
molecules (CAMs) mediate the adhesion of monocytes to the vascular endothelium, an initial
step in atherogenesis. In 27 patients with hypertriglyceridemia and low HDL-C, treatment
with purified n-3 fatty acid (Omacor) 4 g/d for at least 7 months not only reduced
triglyceride by 47% and total cholesterol by 21%, but also reduced levels of soluble
intercellular adhesion molecule 1 (sICAM-1) by 9% (p=0.02) and soluble E-selectin
(sE-selectin) by 16% (p <0.0001). Even greater reductions of soluble CAMs (sCAMs) were
observed in diabetic patients: sICAM-1 was reduced by 27% in the 6 patients with type 2
diabetes (vs. 3% in the patients without diabetes), and sE-selectin was reduced by 32% in
the diabetic patients (vs 12% in patients without diabetes). Reference:
Abe Y, El-Masri B, Kimball KT, Pownall H, Reilly CF, Osmundsen K, Smith CW, Ballantyne CM.
Soluble cell adhesion molecules in hypertriglyceridemia and potential significance on
monocyte adhesion. Arterioscler Thromb Vasc Biol 1998;18:723-731.
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