Many POCs are found toxic to humans. In the United States, as mandated by the Congress, the toxicological properties for some of these chemicals have been systematically assessed by the U.S. Agency for Toxic Substances and Disease Registry (U.S. ATSDR). These regulatory assessment documents are published as separate toxicological profiles for the individual chemicals of concern (e.g., U.S. ATSDR, 2000). The next slide provides an overview of these toxicological properties for the POCs that have been assessed by U.S. ATSDR, U.S. EPA, or WHO. The summary as given in the next slide is by no means comprehensive or complete. For instance, it does not include the few incidents where death was the toxic endpoint after (test) subjects were (accidentally) exposed to or given a sufficiently large dose.