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There are also
fundamental issues concerning the use of ADIs or RfDs for setting tolerance
limits or MRLs. These pre-accepted safe daily intakes are only as accurate
or meaningful as the toxicity data used which are ever lacking. These intake
limits may not have incorporated an adequate safety factor for infants and
children (including pregnant and nursing women), who are known to be more
vulnerable to most chemical exposures. Another concern is that the
toxicologic endpoints used in the MRL or tolerance derivation are different
in severity among (groups of) POCs. It is also important to note that the
ADIs or RfDs used had rarely, if not never at all, addressed the potential
for synergism or additivity of toxicity. |